Lactospore®: Probiotics for Mood, Energy and Gut Balance - RCT Studies

Introduction

In today's fast pace, many struggle with stress, fatigue and stomach upset. The research shows a clear link between gut flora and the brain.

Lactospore® has been tested in randomized controlled trials with concrete results. We go through three RCT studies on this particular spore probiotic.

From depression in IBS to reduced gas and better mental clarity. Spore technology makes it unique - stable and effective in everyday life.

RCT study: Lactospore® against depression and IBS

A 2018 double-blind RCT tested 2 billion CFU Lactospore® on 40 patients with both IBS and depression for 90 days.

The Hamilton Depression Scale dropped significantly from 18 to 10.8 points, p-value 0.01. Also MADRS and CES-D improved markedly after 60 days.

Patients reported 48% better quality of life linked to IBS. The effect built up gradually but was clear towards the end.
The same dosage used in most studies on the strain.

Why did it work?

Lactospore® reduces intestinal inflammation that can otherwise negatively affect the brain. It supports the production of neurotransmitters such as serotonin via the gut-brain axis.

Tip: Take it 30 minutes before your morning meal for optimal activation.

RCT: Lactospore® against gas, bloating and brain fog

A 2023 multicenter study of 70 adults with functional gastric disorders used Lactospore® for 4 weeks. GSRS scores for indigestion dropped by 73% in the probiotics group, compared to 34% for placebo.

85% of participants felt “much better” globally, against just 29% in the placebo group. Brain fog and mental fatigue were significantly improved via validated forms.

Gas and bloating were reduced by 60— 70% in the majority. The same 2 billion CFU dose as in the depression study -- the spore form is crucial.

The connection with everyday energy

Minor physical discomfort from the stomach releases mental energy. Study Shows How Gut Comfort Directly Affects Cognitive

clarity. Try after dinner for evening-related effect on sleep and recovery.

Stress reduction and brain plasticity

Research from 2025 confirms that H. coagulans MTCC 5856 increases BDNF levels in the hippocampus. It counteracts anxiety-like behaviors with p-value below 0.05.

Short-chain fatty acids from intestinal fermentation provide direct energy supply to the brain. The spore form survives 99% of stomach acid and is first activated in the small intestine.

The effects are often visible after 4 weeks of consistent use. Fiber in the diet can enhance colonization up to three times.

Safety of long-term use

A 2023 study of 50 healthy adults tested Lactospore® for 28 days without negative microbiome changes. Blood values for liver and kidney were not affected at all.

Positive shifts in the bacterial balance occurred without disturbing existing flora. The strain has GRAS status since 1996 with a total of 33 clinical studies.

Safe for daily use up to 2 billion CFU over a long period of time. No reported impact on the intestinal barrier in healthy individuals.

How Lactospore® Boosts Energy and Mood

The spore form produces L+ lactic acid and butyrate directly in the large intestine. Butyrate accounts for approximately 70% of the colon's

energy requirements. A stronger intestinal barrier reduces the passage of endotoxins into the bloodstream.

Mechanisms step by step

BDNF is upregulated for better brain plasticity, p<0.05. The NF-κB pathway is inhibited for lower systemic inflammation. Zonulin levels increase for denser intestinal walls.

Prebiotics such as beta-glucan make the effect even stronger. Fermentation can contribute up to 10% of the daily energy requirement. Optimal timing is 30 minutes before meals for activation.

The advantages of SPORE technology

Lactospore® MTCC 5856 is patented since 2008 with over 30 studies. 90% of spores reach the intestine, versus 20— 40% for traditional Lactobacillus strains.

No cooling needed - stable in powder form for several years. It withstands heat, acid and pressure without losing potency. Perfect for travel, workout bags or busy days. Easy to mix in water, shake or smoothies.

Practical tips for best results

Mix one serving with 2-3 cups of water or other beverage. Take 30 minutes before morning meals or immediately after dinner. Eat fermented foods, vegetables and oats as natural prebiotics.

Avoid processed sugars that upset the intestinal balance. In case of stressful periods: Use consistently for 4—8 weeks. For easy tracking, note mood, energy and gut feeling in a journal.

Common Avoidances

Do not bring hot coffee or tea above 50°C - the spores are activated at body temperature. Do not change probiotic strain every 2 weeks - give at least 4 weeks of time.

Exercise significantly enhances the gut-brain effects.

Development of research

Since the groundbreaking 2018 study, five RCTs have confirmed the findings. From IBS depression to functional stomach disorders and stress.

Patent WO2018004586A1 covers use specifically in depression. Primary sources for deep diving: the HAM-D study on PubMed.

The GSRS gas study. Spore probiotics represent the research going forward.

Summary

Lactospore® shows consistent results in RCT studies for mood, energy, and gut comfort. From 48% better quality of life to

73% reduction in gas - the effects are well documented. Try spore probiotics with 2 billion CFU daily to support gut-brain balance.

About Relivo

Relivo is a complete daily nutritional supplement developed in collaboration with Swedish scientists and nutritionists. Relivo combines 38 carefully selected nutrients that support the body's most important systems and structures.

All collected in a scoop in powder form, developed to be easy to use and easy to bring into everyday life. Relivo is blended in 60 seconds and is used as a long-term nutritional foundation for energy, immune system, gut health, muscles and joints.

Sources

• Food and Nutrition Research 2018: Bacillus coagulans MTCC 5856 for IBS and depression (PubMed: 29997457)
• Translational Psychiatry 2023: Effects on Functional Gastric Disorders (PubMed: 36862903)
• Food & Function 2025: Heyndrickxia coagulans as the next generation probiotic
• 33 clinical studies on Lactospore® MTCC 5856 since 1996 (lactospore.com/research)
• Patent WO2018004586A1: Use in major depressive disorder